Biological and Medical Applications of Materials and Interfaces
- Chao Gao
Chao Gao
College of Engineering, China Agricultural University, Beijing 100083, China
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- Juntai Xu
Juntai Xu
Department of Oncology Surgery, Women and Children’s Hospital, Qingdao University, 6 Tongfu Road, Shibei District, Qingdao, Shandong 266034, China
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- Shuangxi Xie
Shuangxi Xie
College of Engineering, China Agricultural University, Beijing 100083, China
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- Wenqiang Zhang*
Wenqiang Zhang
College of Engineering, China Agricultural University, Beijing 100083, China
*Email: [emailprotected]
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- De Gong*
De Gong
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
*Email: [emailprotected]
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- Guanya Peng
Guanya Peng
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
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- Zaihui Du
Zaihui Du
Food Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China
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- Jiacheng Rong
Jiacheng Rong
College of Engineering, China Agricultural University, Beijing 100083, China
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- Xianjun Li
Xianjun Li
College of Engineering, China Agricultural University, Beijing 100083, China
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- Chao Liang
Chao Liang
Department of Precision Instrument, Tsinghua University, Beijing 100084, China
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- Bo Gu
Bo Gu
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
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- Wentao Xu*
Wentao Xu
Food Laboratory of Zhongyuan, Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China
*Email: [emailprotected]
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- Jun Cai
Jun Cai
School of Mechanical Engineering & Automation, Beihang University, Beijing 100191, China
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
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https://pubs.acs.org/doi/10.1021/acsami.4c21531
Published April 16, 2025
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Abstract
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Neuroblastoma, a highly malignant pediatric tumor, demands innovative targeted drug delivery strategies to overcome the limitations of conventional therapies. In this study, we developed magnetic diatom microrobots (DMs) using diatom frustules as biotemplates, leveraging their natural hierarchical porosity and biocompatibility. Functionalized with amino groups and folic acid, these microrobots demonstrated enhanced drug conjugation and tumor-targeting capabilities. Designed to carry either cisplatin (CDDP) or paclitaxel (PTX), the DMs facilitated complementary therapeutic effects through pH-responsive release, enabling synergistic neuroblastoma therapy. Magnetic actuation tests confirmed multimodal propulsion and precise motion control. In vitro experiments demonstrated enhanced therapeutic efficacy and reduced off-target effects compared to those of conventional approaches. These diatom-templated magnetic microrobots, with their facile fabrication and superior performance, represent a promising platform for targeted drug delivery and advanced cancer therapy.
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- Cancer therapy
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- Drug release
- Pharmaceuticals
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ACS Applied Materials & Interfaces
Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX, XXX-XXX
Click to copy citationCitation copied!
Published April 16, 2025
Publication History
Received
Accepted
Revised
Published
online
© 2025 American Chemical Society
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